Biotin and derivatives
Medchemexpress LLC DBCO-NHS ester 2 100mg | 1384870-47-6 | 100 MG
DBCO-C6-NHS ester is a DBCO-derived N-hydroxysuccinimide (NHS) ester used to introduce a DBCO handle onto amine-containing molecules for copper-free, strain-promoted alkyne-azide cycloaddition (SPAAC) bioconjugation and antibody-drug conjugate (ADC) linker synthesis.
- Amine-reactive NHS ester for covalent coupling to primary and secondary amines.
- Facilitates copper-free SPAAC click chemistry with azide-functionalized partners.
- Suitable for bioconjugation, ADC synthesis, and labeling of proteins or small molecules.
- Available in multiple sizes; typical laboratory scale is 100 mg.
- Soluble in DMSO (~14.29 mg/mL); store powder at -20°C for long-term stability.
Medchemexpress LLC N-piperidine ibrutinib hydrochloride | 2231747-18-3 | 98.1% | C22H23ClN6O | 10MG
N-piperidine ibrutinib hydrochloride is a hydrochloride salt derivative used in research as a BTK ligand and synthetic intermediate for targeted degraders. It is supplied as a high-purity solid and as a ready-to-use DMSO solution, and is characterized for potency against wild-type and mutant BTK.
- Potent BTK activity with low-nanomolar IC50s for WT and C481S variants.
- High purity suitable for research applications.
- Available as solid powder and 10 mM solution in DMSO.
- White to yellow solid appearance for easy handling.
- Useful as a ligand in PROTAC synthesis and other chemical biology workflows.
Medchemexpress LLC Bis-PEG21 N-hydroxysuccinimide ester | 2221948-98-5 | 98.0% | 1237.34 | C54H96N2O29 | 50 MG
Bis-PEG21 N-hydroxysuccinimide ester is a polyethylene glycol (PEG21) based homobifunctional NHS ester linker used for bioconjugation. It provides two reactive NHS ester termini for amine coupling and a long PEG spacer to increase solubility and flexibility, making it suitable for PROTAC and antibody-drug conjugate (ADC) synthesis.
- PEG21 spacer increases solubility and molecular flexibility.
- Two NHS ester groups enable efficient amine coupling.
- Suitable as a cleavable linker in ADC and PROTAC applications.
- High purity with analytical data and a certificate of analysis available.
- Available in multiple pack sizes; supplier data notes a 50 MG pack though manufacturer lists 100 MG as the smallest standard pack.
![Medchemexpress LLC 2,5-Pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | 95.0% | 356.28 g/mol | C14H16N2O9 | 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202007.png-250.jpg)
Medchemexpress LLC 2,5-Pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | 95.0% | 356.28 g/mol | C14H16N2O9 | 5 G
Bis-PEG1-NHS ester is a non-cleavable, short polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester groups. It is used to couple agents to primary amines via stable amide bond formation, providing a hydrophilic spacer that improves solubility and spacing in bioconjugates.
- Non-cleavable 1-unit PEG spacer.
- Two NHS ester groups for amine-reactive conjugation.
- Forms stable amide bonds with primary amines.
- Increases aqueous solubility of conjugates.
- Suitable for antibody-agent conjugation and general bioconjugation workflows.